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Effects of pregabalin (PGB, 20–80 mg/kg i.v. injection) on spinally-organized nociception were investigated in isoflurane-anesthetized intact and spinalized rats. Responses of single deep spinal dorsal horn (DH) (laminae IV–V) nociceptive-specific (NS) neurons receiving peripheral inputs from A-δ and C fibers to repetitive electrical stimulation (intensity: 3–5 mA; frequency: 1 Hz; pulse duration:...
The purpose of this study was to investigate sex-related differences in nociception elicited by s.c. injection of different concentrations (1–5%) of formalin. S.c. formalin-induced biphasic (early and late phases) persistent nociception was assessed by extracellularly recording the spontaneous activities of single spinal dorsal horn wide-dynamic range neurons in anesthetized male and female rats....
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