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To assess structural brain changes in survivors of acute lymphoblastic leukemia (ALL) with chemotherapy treatment by combining voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS).28 ALL patients (mean age: 40.71±8.58years, years since diagnosis: 7–38) and 20 age-matched control subjects (mean age: 42.95±6.39years) selected in this study with 3D T1 and diffusion tensor imaging acquired...
Amyloid precursor protein (APP) and β-site amyloid precursor protein cleaving enzyme (BACE-1) play important roles in the generation of Alzheimer׳s disease (AD), a progressive neurodegenerative disorder. In the present study, microRNA (miR) microarray was used to analyze the miR expression profiles in the hippocampi from APP/PS1 transgenic and wild type mice. The miRs with significant alteration and...
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