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An unexpected reaction of aldimines and difluoroenoxysilane promoted with Zn(OTf) 2 was disclosed. The reaction gave the unexpected Mukaiyama-aldol adducts 3 in excellent yields (up to 87%) with the addition of H 2 O and the corresponding Mannich-type adduct 4 was not observed in this catalytic system.
Catalytic asymmetric vinylogous Mannich (AVM) reactions of readily available aldimines with trimethylsiloxyfuran in the presence of catalytic amount of AgOAc and chiral phosphine-Schiff base type ligands are described, affording the corresponding products in up to 91% yield, anti/syn >99:1 and 81% ee.
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