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Recent advances in DNA microarrays technology provides detailed information on genomic aberrations in tumor cells. DNA copy number changes and loss-of-heterozygosity (LOH) are types of genomic aberrations which are identified using SNP arrays. The heterogeneity of clinical tumor tissue severely affects copy number analysis where tumor tissue has a large proportion of normal stromal cells. This may...
Copy number change is an important form of structural variation in human genomes. Somatic copy number alterations can cause the acquisition of oncogenes and loss of tumor suppressor genes in tumorigenesis. Recent development of SNP array technology facilitates studies on copy number changes in a genome-wide scale with high resolution. However, tumor samples often consist of mixed cancer and normal...
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