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Eight novel 1,4-disubstituted phthalazines (7–14) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR, 1 H NMR, 13 C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin.
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