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Data suggest that periodontal disease (periodontitis) may be a risk factor for rheumatoid arthritis. Anti-citrullinated peptide/protein antibodies (ACPA) are highly specific for rheumatoid arthritis, and epitope spreading arises years before clinical onset of the disease. The purpose of this study was to determine the immune reactivity to ACPA and their uncitrullinated control peptides in patients...
Although chronic obstructive pulmonary disease (COPD) is one of the most deadly, prevalent, and costly chronic diseases, no comprehensive estimates of the risk of developing COPD in the general population have been published. We aimed to quantify the lifetime risk of developing physician-diagnosed COPD in a large, multicultural North American population. We did a retrospective longitudinal cohort...
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