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Previous studies have suggested that mice passively sensitized with anti-dinitrophenol (DNP) monoclonal IgE antibody exhibit a triphasic cutaneous reaction with an immediate-phase response (IPR) at 1 h, a late-phase response (LPR) at 24 h and a very late-phase reaction (vLPR) at 8 days after challenge with 2,4-dinitrofluorobenzene. The present study was conducted to elucidate the role of T cells in...
Some retinoids show an anti-inflammatory action through regulation of transcription of various genes. In the present study, the inhibitory effect of 4-((5,6,7,8- tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) carbamoyl) benzoic acid (Am-80), a synthetic retinoid, on mouse contact hypersensitivity provoked by repeated applications of 2,4-dinitrofluorobenzene (DNFB) to the ear was investigated. Five-fold...
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