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S‐epacadostat (S‐EPA) is an efficient and selective small‐molecule inhibitor of indoleamine 2,3‐dioxygenase 1. It is an EPA analog with a sulfur atom instead of a nitrogen atom at the furazan C3 position. This study documents the pharmacokinetics of S‐EPA in dogs and its metabolic pathway. After an oral administration of 15 mg/kg of S‐EPA in dogs, the time to peak concentration was 0.80 h, the mean...
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