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Aging is associated with exacerbated brain injury after ischemic stroke. Herein, we explored the possible mechanisms underlying the age-associated exacerbated brain injury after ischemic stroke and determined whether therapeutic intervention with anesthetic post-conditioning would provide neuroprotection in aged rats. Male Fisher 344 rats (young, 4months; aged, 24months) underwent 2h of middle cerebral...
Tumour necrosis factor-α (TNFα) is a cytokine that induces apoptosis in various cell systems by binding to a TNF receptor (TNFR). To study TNFα-induced apoptosis, we isolated and characterized a novel TNFα resistant variant, U937/TNF clone II-5, from human monocytic leukaemia U937 cells. The II-5 cells resist apoptosis by TNFα and anti-Fas antibody but not by anticancer drugs, such as VP-16 and Ara-C...
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