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Grapefruit juice changes the pharmacokinetic parameters of a variety of drugs metabolized primarily by cytochrome P450 3A. In a three-phase crossover study, six male beagle dogs were administered 100ml of water (control), 100ml of commercial liquid grapefruit juice, or 10g of freeze-dried grapefruit juice (equivalent to 100ml of liquid grapefruit juice) with 100ml of water, followed after 2h by single...
In this overview the authors describe the use of Tanax®(T-61) for euthanasia. Tanax®is a solution with three components (embutramide, mebenzonium iodide and tetracaine hydrochloride) used for painless death in pets and laboratory animals. It is also used for malicious intoxication in animals and for suicide attempts in humans. After a description of the modality and outcome of intoxication, the authors...
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