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Immunotherapy
In article 2212267, Haihua Xiao, Nianzeng Xing, and co‐workers present a novel therapeutic strategy to achieve synergistic cancer immunotherapy via cuproptosis induced by reactive oxygen species (ROS)‐responsive nanomedicine loaded with elesclomol and copper (NP@ESCu). With this approach, the tumor microenvironment is reprogrammed, and the expression of PD‐L1 is increased, which consequently...
Cuproptosis is a new cell death that depends on copper (Cu) ionophores to transport Cu into cancer cells, which induces cell death. However, existing Cu ionophores are small molecules with a short blood half‐life making it hard to transport enough Cu into cancer cells. Herein, a reactive oxygen species (ROS)‐sensitive polymer (PHPM) is designed, which is used to co‐encapsulate elesclomol (ES) and...
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