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Background
Glomerular endothelial cells (GECs) are directly exposed to circulating viral particles in the glomerulus. Although viral infections may trigger the development of acute kidney injury or the worsening of pre‐existing chronic kidney disease, the specific molecular mechanisms underlying antiviral reactions via the activation of endothelial Toll‐like receptor 3 signaling in the kidney remain...
Since viral infections activate type I interferon (IFN) pathways and cause subsequent release of IFN‐dependent proinflammatory chemokines and cytokines, the innate immune system plays an important role in the pathogenesis of lupus nephritis (LN). It has been reported that human myxovirus resistance protein 1 (Mx1), a type I IFN‐dependent transcript, acts against a wide range of RNA viruses. Although...
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