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The binding of actinomycin D (C 1 , 1) and its analog actinomin (2) was studied on base-modified oligonucleotide duplexes with parallel chain orientation (ps) and with anti-parallel chains (aps) for comparison. Actinomycin D binds not only to aps duplexes containing guanine–cytosine base pairs but also to those incorporating modified bases such as 7-deazaguanine or its 6-deoxo derivative....
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