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In Situ Endothelialization
In article number 2103490, Lei Dong, Chunming Wang, and co‐workers describe how fungal sugars in bioscaffold design are mimicked to support vascular growth. When microbes invade human tissue, their surface carbo hydrates bridge the endothelium for further transmigration. Glucomannans are chemically modified and electrospun into a fibrous scaffold, which recruits galectins...
The globally high prevalence of peripheral artery diseases poses a pressing need for biomaterials grafts to rebuild vasculature. When implanted, they should promote endothelial cells (ECs) adhesion both profoundly and selectively—but the latter expectation remains unfulfilled. Here, this work is inspired by fungi that invade blood vessels via the “bridge” of galectins that, secreted by ECs, can simultaneously...