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We report the synthesis and biological activity of a low molecular weight non-peptidic mimic of the analgesic peptide ω-conotoxin GVIA. The molecular weight of this compound presents a reduction by 193g/mol compared to a previously reported lead. This compound exhibits an EC 50 of 5.8μM and is accessible in only six synthetic steps compared to the original lead (13 steps). We also report several...
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