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The intervertebral disc (IVD) degeneration is initiated by cartilage endplate (CEP) degeneration and is characterised by reduced chondrification. Cartilage endplate-derived stem cells (CESCs) with chondrogenic differentiation abilities are responsible for the restoration of cartilage. CEP remains in an avascular and hypoxic microenvironment. In this study, we observed that the physiological hypoxia...
Homeobox genes play important roles in limb development.Backfootis a recently identified mammalian homeobox gene whose temporal and spatial expression pattern during limb development suggests that it is a key component for specifying the identity and structure of the hindlimb. Here we report the chromosomal mapping of theBackfootlocus in human (BFT) and mouse (Bft). Using single-strand conformation...
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