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The aim of the work was to determine the effect of body fat change on risk of diabetes in normal glucose tolerance (NGT) population. A total of 1,857 NGT subjects were included and followed up for an average period of 44.57 months. Body fat percentage (BF%) was measured by bioelectrical impedance analysis. Subjects were grouped based on the BF% and/or body mass index (BMI) state. Among all subjects,...
β‐Cell dedifferentiation, characterized by loss of glucose sensitivity (β‐cell glucose sensitivity [βCGS]), has been reported to play an important role in the development of type 2 diabetes (T2D). Traditionally, βCGS was derived from C‐peptide‐based method. However, C‐peptide was not routinely examined in normal subjects and diabetes never treated with insulin. Thus, the aim of the study was to evaluate...
Inflammation is the most important link between obesity and type 2 diabetes (T2D). Although milk fat globule‐epidermal growth factor 8 (MFG‐E8) is a key mediator in anti‐inflammatory responses, its role in obesity and diabetes is not yet completely understood. We aimed to measure MFG‐E8 serum levels and to explore the role of MFG‐E8 in obesity and T2D. Fasting serum MFG‐E8 levels were quantified by...
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