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Background
Prostate cancer (PCa) is a clinically heterogeneous disease. The creation of an expression‐based subtyping model based on prostate‐specific biological processes was sought.
Methods
Unsupervised machine learning of gene expression profiles from prospectively collected primary prostate tumors (training, n = 32,000; evaluation, n = 68,547) was used to create a prostate subtyping classifier...
Background
Salvage immunochemotherapy followed by high‐dose chemotherapy and autologous stem cell transplantation is the standard‐of‐care second‐line treatment for patients with relapsed/refractory diffuse large B‐cell lymphoma after first‐line R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Outcomes after receipt of second‐line immunochemotherapy in patients with...
BACKGROUNDThe current study was conducted to explore the relationship between icotinib hydrochloride exposure and therapeutic effects in Chinese patients with advanced non‐small cell lung cancer (NSCLC) who were treated with icotinib hydrochloride.
METHODSA total of 30 patients with NSCLC who were treated with icotinib hydrochloride were chosen from a single‐center, open‐label, phase 1 dose escalation...
Since the discovery of epidermal growth factor receptor mutations and epidermal growth factor receptor tyrosine kinase inhibitors, lung cancer treatment in China has entered the precision era. However, novel targeted agents based on novel biomarkers still need to be developed. In the current study, the authors review the biomarker features of lung cancer in the Chinese population and the novel agents...
BACKGROUND:Although oral leukoplakia (OL) is the best‐known potentially malignant disorder, the risk of OL malignant transformation is difficult to assess. ATP‐binding cassette, G2 subfamily (ABCG2) and BMI‐1 are stem cell markers that have been found to be associated with head and neck tumorigenesis. The objective of the current study was to evaluate the usefulness of ABCG2 and BMI‐1 in predicting...
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