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Purpose
Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease characterized by small‐airway obstruction and alveolar‐airspace destruction. Hyperpolarized 129Xe diffusion MRI of lung is a promising biomarker for assessing airspace enlargement, but has yet to be validated by direct comparison to lung histology. Here we have compared diffusion measurements of hyperpolarized (HP)...
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