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This study evaluated the effects of melatonin on spinal cord injury (SCI)‐induced oxidative damage in testes. Adult male C57BL/6 mice were randomly divided into sham‐, SCI‐ or melatonin (10 mg/kg, i.p.)‐treated SCI groups. To induce SCI, a standard weight‐drop method that induced a contusion injury at T10 was used. After 1 week, testicular blood flow velocity was measured using the Laser Doppler Line...
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disorder, which is characterized by raised serum bile acid level and potential adverse fetal outcome. Farnesoid X receptor (FXR), also known as a bile acid receptor, was found to be expressed in placenta with low level. Whether activation of FXR by specific agonists could regulate the pathogenesis of ICP is still unclear.A model of...
There is a growing body of evidence to support the direct link between obstructive bladder dysfunction and erectile dysfunction (ED). However, there have been few pathophysiological studies to determine the relationship between lower urinary tract syndrome (LUTS) and ED. As the transforming growth factor‐β1 (TGF‐β1) that induces the synthesis of collagen in the penile tissues is critical for the development...
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