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Background
Myoclonus‐dystonia is a neurogenic movement disorder caused by mutations in the gene encoding ɛ‐sarcoglycan. By contrast, mutations in the α‐, β‐, γ‐, and δ‐sarcoglycan genes cause limb girdle muscular dystrophies. The sarcoglycans are part of the dystrophin‐associated protein complex in muscle that is disrupted in several types of muscular dystrophy. Intriguingly, patients with myoclonus‐dystonia...
Background:Mutations in the maternally imprinted epsilon‐sarcoglycan gene occur in 30%–50% of myoclonus‐dystonia cases. Psychiatric symptoms, particularly obsessive‐compulsive disorder, have been described in some patients.
Methods:We systematically reviewed 22 reports of psychiatric symptoms in myoclonus‐dystonia, dividing individuals according to clinical and mutation status.
Results:Clinically...
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