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A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer's disease (AD).Plasma amyloid beta (Aβ) 1–40 , Aβ 1–42 , Aβ n–40 , and Aβ n–42 peptides were measured at baseline and after 18 months in 771 participants from the Australian Imaging Biomarkers and Lifestyle (AIBL) study of aging. Aβ peptide levels were compared with clinical pathology,...
Alzheimer's disease (AD) is an epidemic facing the entire world. Increased knowledge gained during the past 25 years indicates that AD falls along a clinical and neuropathological spectrum represented as a continuum that extends from preclinical disease in which there are no symptoms, through early symptomatic phases, and finally to AD dementia. The Alzheimer's research community recognizes that imaging,...
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