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GABA B receptor agonists have been reported to have both pro- and antiepileptic properties. Here, the effects of a GABA B receptor agonist, baclofen, were studied on epileptiform activity induced in the absence of synaptic transmission — to focus on the postsynaptic effects. Perfusion of hippocampal slices with 0-added calcium and high potassium induced field bursts in CA1 and the...
The increased propensity of the immature brain to have seizures may be due, in part, to an inability to regulate the extracellular ionic environment. Here, we tested the regulation of extracellular pH in the developing hippocampus during and after intense neuronal activity induced by 20 Hz electrical stimulation in vivo. In CA1, stimulus trains to the CA3 region elicited an early alkaline shift associated...
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