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Classification of G protein-coupled receptors (GPCRs) according to their functions is an ongoing area of research which is helpful for the pharmaceutical industry in the development of drug targets for major diseases. Currently, more than 40% drugs in the market target GPCRs. The experimental methods of determining their function are very expensive and time consuming. Due to a rapid and constant increase...
Many artificial intelligence techniques have been developed to process the constantly increasing volume of data to extract meaningful information from it. The accurate annotation of the unknown protein using the classification of the protein sequence into an existing superfamily is considered a critical and challenging task in bioinformatics and computational biology. This classification would be...
The process of mapping markers from radiation hybrid mapping (RHM) experiments is equivalent to the traveling salesman problem and, thereby, has combinatorial complexity. As an additional problem, experiments typically result in some unreliable markers that reduce the overall quality of the map. We propose a clustering approach for addressing both problems efficiently by eliminating unreliable markers...
Bioinformatics has been emerging as a new research dimension since the last century by combining computer science and biology techniques for the automatic analysis of biological sequence data. The volume of the biological data gathered under different sequencing projects is increasing exponentially. These sequences contain extremely important information about genes, their structure and function....
Radiation Hybrid Mapping (RHM) provides a means of ordering markers on a chromosome. The process of mapping markers is equivalent to the traveling salesman problem, and thereby has combinatorial complexity. Addressing this computational complexity for a large number of markers is one problem addressed in the presented research. A related problem is that the quality of mapping information differs across...
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