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The N-methyl-d-aspartate receptor (NMDAR) is important for learning. Lead (Pb) exposure impairs learning ability and affects the NMDAR. This study tested whether developmental exposure to a combination of Pb, zinc (Zn), and magnesium (Mg) would result in effects different from those seen with individual metals. Fischer 344 (F344) rat pups of both genders were exposed from gestation day 5 to post-natal...
F344 rats were exposed to drinking water mixtures of seven of the most common groundwater contaminants associated with hazardous waste sites [arsenic, benzene, chloroform, chromium, lead, phenol, and trichloroethylene (TCE)] as the full mixture or submixtures of the organic and/or inorganic chemicals. The lowest concentrations (1x) of the individual chemicals were environmentally realistic and below...
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