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We found a significant elevation in the IL-1β mRNA content in the hippocampus of SAMP8 in comparison with that of SAMR1 at 10 months after birth. In both senescence-accelerated mouse (SAM) strains, the increases in brain IL-1β protein were more noticeable at 10 months than at 2 or 5 months. The only differences found in protein levels between strains were at 10 months and consisted of elevations in...
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