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To compare large numbers of genomic sequences of related virus, such as HIV, biologists have an increasing need for a method that can efficiently handle hundreds, even thousands, of genomic sequences accurately enough to correctly align these conserved features. In this paper, we introduce a new and efficient tool named SMA that can easily accommodate large-scale virus genomic sequences. A high-throughput...
To compare large genomic DNA sequences of related organisms and of different species, researchers need efficient methods to align many long sequences. We developed a new tool super multiple genome alignment (SMGA for short), specially for rapid multiple global alignment of genomic sequences. SMGA can align a data set consisting of 50M of 9 enterobacterial genomic sequences in 40 minutes. Our method...
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