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We investigated the molecular mechanisms by which 5-aza-2′-deoxycytidine (DAC) and paclitaxel (PTX) use lymphoid enhancer-binding factor 1 (LEF1) and the Wnt/β-catenin pathway to synergistically interact against renal cell carcinoma (RCC). LEF1 expression was examined by real-time PCR and immunohistochemistry. The regulation of LEF1/β-catenin protein expression by DAC and/or PTX was examined by Western...
To determine the synergy of 5-aza-2′-deoxycytidine (DAC) and paclitaxel (PTX) against prostate carcinoma (PC) cells by isobolographic analysis. We demonstrated that DAC could significantly increase the susceptibility of PC cells to PTX, and confirmed the synergy of DAC and PTX. DAC enhanced the PTX induced up-regulation of caspase activity and antiproliferative effect, resulting in an increase of...
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