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In this paper, an integrated low-noise patch-clamp amplifier for a solid-state nanopore application is proposed which is composed of three stages: 1) a trans-impedance amplifier (TIA), 2) a voltage-gain amplifier (VGA), and 3) a unity-gain buffer. Because the first stage amplifier makes dominant impacts on gain, bandwidth, noise, stability, and area of the patch-clamp amplifier, in this work, we present...
We present an integrated, low noise patch-clamp amplifier for biological nanopore applications. Our amplifier consists of an integrator-differentiator architecture coupled with a novel opamp design in the CMOS 0.35 μm process. The post-layout full-chip simulation shows the input referred noise of the amplifier is 0.49 pA RMS over a 5 kHz bandwidth using a verified electrical model for the biological...
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