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Exercise is an effective therapy for insulin resistance. However, the underlying mechanism remains to be elucidated. Previous research demonstrated that TGFβ‐activated kinase 1 (TAK1)‐dependent signaling plays a crucial character in hepatic insulin resistance. Hepatic ubiquitin specific protease 4 (USP4), USP18, and dual‐specificity phosphatases 14 (DUSP14) can suppress TAK1 phosphorylation, besides...
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