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The mammalian placenta is essential for supplying nutrients (e.g., amino acids and water) and oxygen from the mother to fetus and for removing fetal metabolites (e.g., ammonia and CO2) from fetus to mother. Thus, placental growth and development are determinants of fetal survival, growth, and development. Indeed, low birth weight is closely associated with reduced placental growth. Providing gestating...
Embryonic loss and intrauterine growth restriction (IUGR) are significant problems in humans and other animals. Results from studies involving pigs and sheep have indicated that limited uterine capacity and placental insufficiency are major factors contributing to suboptimal reproduction in mammals. Our discovery of the unusual abundance of the arginine family of amino acids in porcine and ovine allantoic...
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