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In order to study the mechanism of abnormal macrophage (Mϕ) function in pro-inflammatory cytokine changes after burn, the inositol lipid signal system and its role in tumour necrosis factor-alpha (TNF-α) secretion by peritoneal Mϕs was observed in severely scalded mice.Eighteen percent total body surface area (TBSA) full-thickness scalded mice were used as animal model in this experiment. Peritoneal...
The specific aim of this study was to investigate the pharmacokinetic parameters of antibiotics represented by vancomycin and amikacin in the subeschar tissue fluid (STF) in patients with early stage severe burn. Twenty patients were studied: age 30.7±8.0 years old, weight 60.6±8.4kg, total burn surface area (TBSA) 68.39±17.85%, creatinine clearance (CCr) 95.45±23.14ml/min, mean±S.D. Patients received...
To explore the mechanism of altered tumor necrosis factor-alpha (TNF-α) expression by peritoneal macrophages (PMΦ) and Panax notoginseng saponins (PNS) modulation in light of NF-κB signal transduction in severely scalded mice.Eighteen percent total body surface area (TBSA) full-thickness scalded mice were used. PMΦ was collected at different time intervals (0, 2, 6, 12, 24 and 48 post-burn hour (PBH))...
Objective: to investigate the biological activity of subeschar tissue fluid (STF) and its probable mechanism in the genesis of systemic inflammatory response syndrome(SIRS). Methods: the changes of heart rate (HR), respiratory rate (RR), white blood cell count (WBCC) as well as the major organ function were observed in the animals injected with STF. The inflammatory mediators TNF-α and IL-1 in the...
Fourteen cases suffering full-thickness burns of more than 70 per cent total body surface area (TBSA) have been successfully treated during the last 8 years (1988-1995). Among these patients, 10 cases suffered from burns of more than 90 per cent TBSA. Five cases had full-thickness burns of 80-90 per cent TBSA. Escharectomy, followed by coverage of wounds with a homograft to the lower surface of...
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