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Macrophage-colony stimulating factor (M-CSF) is crucial for macrophage survival; however, the mechanism associated with this signaling has not been fully elucidated. Here, we identified pleckstrin homology domain-containing family O member 2 (PLEKHO2), a protein with unknown function, as a novel regulator of macrophage survival in vitro and in vivo. We found that PLEKHO2-deficient mice exhibited severe...
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