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Metastasis of cancer to bone is one of the most significant causes of morbidity and often indicates poor prognosis particularly for breast cancer, prostate cancer, and lung cancer patients. Animal models are important tools to investigate the pathogenesis of, and develop novel treatment strategies for, bone metastases in humans. The ideal animal model of bone metastatic human cancer would reproduce...
Summary The development of new biochemical markers of bone metabolism has greatly enriched the array of analytes used in the assessment of skeletal pathologies. When applied and interpreted correctly, these indices may be useful in the work-up of patients with metabolic or malignant bone disease. Although they are not suitable for establishing the diagnosis of osteoporosis...
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