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Glioblastoma (GBM) is a high‐grade adult‐type IDH‐wildtype diffuse glioma, commonly harboring epidermal growth factor receptor (EGFR) amplification. Here, we describe a case of a 49‐year‐old man with a GBM harboring a TERT promoter mutation. Despite surgical and chemoradiation therapy, the tumor recurred. At that time, comprehensive genomic profiling by next‐generation sequencing identified two rare...
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