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Medical imaging through a targeting agent promises to improve the specificity and sensitivity of cancer detection. Nanoparticles (NPs) may provide advantages for targeted photoacoustic (PA) imaging due to their unique physical and optical properties. In our previous study, we developed a phase-change contrast agent made from a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA) and loaded...
In this study, a phase-change contrast agent made of biodegradable polymer PLGA and loaded with gold nanorods (GNRs) and perfluorohexane were conjugated to an anti-HER2 antibody (Herceptin) for specific binding to breast cancer cells that overexpress HER2 receptors. The mean size of the nanoparticles (NPs) was about 500 nm. The targeting specificity of PLGA-GNR-Herceptin NPs was examined using fluorescent...
Poly (lactide-co-glycolic acid) (PLGA) particles are biocompatible FDA approved materials that can be used for diagnostic and therapy applications. Micron-sized PLGA particles were synthesized with gold nanoparticles and DiI dye within the PLGA shell, and perfluorohexane liquid (PFH) in the core. The liquid core is activated upon laser irradiation, resulting in a rapidly expanding microbubble; damage...
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