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Objective
To determine how best to use magnetic resonance imaging (MRI) and targeted MRI/ultrasonography fusion biopsy for early detection of prostate cancer (PCa) in men with elevated prostate‐specific antigen (PSA) concentrations and whether it can be cost‐effective.
Methods
A Markov model of PCa onset and progression was developed to estimate the health and economic consequences of PCa screening...
BACKGROUND
Active surveillance (AS) for prostate cancer includes follow‐up with serial prostate biopsies. The optimal biopsy frequency during follow‐up has not been determined. The goal of this investigation was to use longitudinal AS biopsy data to assess whether the frequency of biopsy could be reduced without substantially prolonging the time to the detection of disease with a Gleason score ≥...
BACKGROUND:Limited survival benefit and excess treatment because of prostate‐specific antigen (PSA) screening in randomized trials suggests a need for more restricted selection of prostate biopsy candidates by discerning risk of histologically aggressive versus indolent cancer before biopsy.
METHODS:Subjects undergoing first prostate biopsy enrolled in a multicenter, prospective cohort of the National...
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