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Recently, we demonstrated elevated numbers of CD4+ Foxp3+ regulatory T (Treg) cells in Plasmodium yoelii‐infected mice contributing to the regulation of anti‐malarial immune response. However, it remains unclear whether this increase in Treg cells is due to thymus‐derived Treg cell expansion or induction of Treg cells in the periphery. Here, we show that the frequency of Foxp3+ Treg cells expressing...
The role of Foxp3+ regulatory T (Treg) cells in the course of the early hyper‐inflammatory and subsequent hypo‐inflammatory phases of sepsis is ambiguous. Whereas Nrp1 expression has been reported to discriminate natural Treg cells from induced Treg cells, the Treg cell stability depends on the methylation status of foxp3‐TSDR. To specifically evaluate the role of Foxp3+ Treg cells in the early and...
The epigenetic regulation of transcription factor genes is critical for T‐cell lineage specification. A specific methylation pattern within a conserved region of the lineage specifying transcription factor gene FOXP3, the Treg‐specific demethylated region (TSDR), is restricted to regulatory T (Treg) cells and is required for stable expression of FOXP3 and suppressive function. We analysed the impact...
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