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A recent study published by Muslikhov et al. (Biochemistry (Moscow), 79, 435–439 (2014)) showed that arachidonic acid increases cytosolic Ca2+ concentrations in C2C12 skeletal myotubes mainly via activation of the ryanodine (RY) receptor 1. These results are consistent with the data from another study demonstrating that arachidonic acid targets RY receptor 2 in clonal and primary pancreatic β-cells...
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