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Lynch Syndrome (LS) is an autosomal dominant genetic condition that causes a high risk of colorectal cancer. The hallmark of LS is genetic instability as a result of mismatch repair (MMR) deficiency, particularly in repetitive low complexity regions called microsatellites (MS). MLH1−/− mice deficient in MMR are prone to developing tumors in the colon, upon oral administration of dextran sodium sulfate...
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