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Multi-pinhole collimation is commonly used to improve image quality in small animal SPECT. However multiplexed pinhole projections may introduce ambiguity in image reconstruction and may cause image artifacts and inaccurate quantification. We investigated strategies to optimize data sampling and minimize artifacts, including varying the pinhole configuration and providing a CT-based seed for iterative...
A multi-pinhole collimation device for small animal single photon emission computed tomography (SPECT) uses the gamma camera detectors of a standard clinical SPECT scanner. The collimator and animal bed move independently of the detectors, and therefore their motions must be synchronized. One approach is manual triggering of the SPECT acquisition simultaneously with a programmed motion sequence for...
Diffusion tensor (DT) images quantify connectivity patterns in the brain while the T1 modality provides high-resolution images of tissue interfaces. Our objective is to use both modalities to build subject-specific, quantitative models of fiber connections in order to discover effects specific to a neural system. The health of this thalamo-cortical network is compromised by traumatic brain injury,...
Water diffusion measurements have been shown to be sensitive to tissue cellular size, extra cellular volume, and membrane permeability. Therefore, diffusion tensor imaging (DTI) by MRI can be used to characterize highly cellular regions of tumors versus acellular regions, distinguishing cystic regions from solid regions. An automatic segmentation method is proposed in this paper based on a multi-phase...
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