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Recently, nanozyme‐based photothermal‐catalytic therapy has emerged as a promising strategy for antitumor treatment. Extensive research has focused on optimizing the catalytic activity and photothermal conversion performance of nanozymes through size, morphology, and surface property regulations. However, the biological effects of nanozymes, such as cellular uptake and cytotoxicity, resulting from...
Patients with osteoporotic fractures often require effective fixation and subsequent bone repair. However, currently available materials are often limited functionally, failing to improve this cohort's outcomes. Herein, kaempferol‐loaded mesoporous bioactive glass nanoparticles (MBGNs)‐doped orthopedic adhesives are prepared to assist osteoporotic fracture fixation and restore dysregulated bone homeostasis,...
Multidrug Delivery Microrobots
Dong Sun and co‐workers fabricate the multidrug delivery microrobot by a step‐by‐step 3D printing method using different biodegradable materials. It includes three components: skeleton, head, and body. The skeleton can respond to magnetic fields for microrobot actuation and drug‐targeted delivery. The drugs are separately stored in the head and body to enhance the synergistic...
Multidrug combination therapy provides an effective strategy for malignant tumor treatment. This paper presents the development of a biodegradable microrobot for on‐demand multidrug delivery. By combining magnetic targeting transportation with tumor therapy, it is hypothesized that loading multiple drugs on different regions of a single magnetic microrobot can enhance a synergistic effect for cancer...
Photothermal therapy (PTT) is demonstrated to be an effective methodology for cancer treatment. However, the relatively low photothermal conversion efficiency, limited tumor accumulation, and penetration still remain to be challenging issues that hinder the clinical application of PTT. Herein, the core–shell hierarchical nanostructures induced by host–guest interaction between water‐soluble pillar[5]arene...
Photothermal Therapy
In article number 2200588, Xiaohuan Sun, Jie Han, and co‐workers construct size switchable core–shell nanostructures regulated by the tumor acidic microenvironment for benefits of both tumor accumulation and penetration. Superior photothermal performance of the core–shell nanostructures is achieved at the tumor site. The nanoplatform is demonstrated for improved antitumor efficacy...
Mitochondrial dysfunction is considered to be an important factor that leads to aging and premature aging diseases. Transferring mitochondria to cells is an emerging and promising technique for the therapy of mitochondrial deoxyribonucleic acid (mtDNA)‐related diseases. This paper presents a unique method of controlling the quality and quantity of mitochondria transferred to single cells using an...
Mitochondrial Transfer
In article number 2103086, Gang Li, Dong Sun, and co‐workers present a novel method of controlling the quality and quantity of mitochondria transferred to single cells using an automated optical tweezer‐based micromanipulation system. The transfer of isolated mitochondria from fetal mesenchymal stem cells (fMSCs) to adult mesenchymal stem cells (aMSCs) by the developed system...
Recent progress in nanotechnology and the ancient use of sulfur in treating dermatological disorders have promoted the development of nano‐sulfides for antimicrobial applications. However, the variable valences and abundant forms of nano‐sulfides have complicated investigations on their antibacterial activity. Here, carbon nanospheres (CNSs) with decoration of ultrasmall FeS2 nanoparticles (CNSs@FeS...
Precise delivery of therapeutic cells to the desired site in vivo is an emerging and promising cellular therapy in precision medicine. This paper presents the development of a magnet‐driven and image‐guided degradable microrobot that can precisely deliver engineered stem cells for orthotopic liver tumor treatment. The microrobot employs a burr‐like porous sphere structure and is made with a synthesized...
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