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BackgroundRecombinant adeno‐associated virus (rAAV) are the most promising vectors for gene therapy. However, large‐scale rAAV production remains a challenge for the translation of rAAV‐based therapeutic strategies to the clinic. The baculovirus expression vector system (BEVS) has been engineered to produce high rAAV titers in serum‐free suspension cultures of insect cells.
MethodsThe typical approach...
The production of virus-like particles (VLP) is of interest to several fields. However, little is known about their assembly when they are expressed in insect cells, as it occurs in conditions different to those of native virus. Knowledge of the localization of recombinant proteins and of the site of accumulation of VLP can increase the understanding of VLP assembly and be useful for proposing production...
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