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To determine the incidence, developmental potential, and clinical implications of embryos having one pronucleus (1PN) or three pronuclei (3PN) at early cleavage, despite exhibiting 2PN at the fertilization check.Retrospective cohort study.Hospital-based academic medical center.All IVF cycles from January 2006 through May 2008 having 2PN zygotes that subsequently transitioned to 1PN or 3PN before cleavage,...
To test the hypothesis that intracytoplasmic sperm injection (ICSI) overcomes a high incidence of tripronucleate zygotes resulting from standard insemination in a previous cycle.A retrospective analysis of matched-pair cycles.Assisted reproductive technologies (ART) program of Brigham and Women’s Hospital.Ninety-five patients with a ≥20% incidence of tripronucleate zygotes in an IVF cycle with use...
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