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A number of kainate receptor antagonists have shown selectivity for receptors containing the GluK1 subunit. Here, we analyze the effects of these GluK1 antagonists on currents mediated by recombinant homomeric GluK3 and heteromeric GluK2/3 receptors expressed in HEK 293 cells and activated by fast application of glutamate. We show that, amongst these compounds, UBP302, UBP310 and UBP316 effectively...
There is considerable interest in understanding long-term potentiation (LTP) of glutamatergic synaptic transmission because the molecular mechanisms involved in its induction and expression are believed to be critical for learning and memory. There are two distinct forms of LTP. One type is triggered by synaptic activation of NMDA receptors and the other is NMDA receptor-independent. The latter type...
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