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Purpose The effect of gastrectomy on pharmacokinetics after S-1 administration was investigated. Patients and methods A dose of 40 mg/m2 of S-1 was administered orally twice daily for 7 days (80 mg/m2/day) preoperatively in ten patients with resectable gastric cancer, and the same dose of S-1 was administered for 28 consecutive days after gastrectomy. Plasma concentrations of tegafur, gimeracil,...
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