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Asialoglycoproteins are internalized via specific receptors localized on the hepatic parenchymal cells. The role of vacuolar type H + -ATPase (v-ATPase) and vacuolar pH in intracellular transport of asialoglycoproteins was investigated in isolated rat hepatocyte couplets. Two specific inhibitors of v-ATPase, bafilomycin A1 and concanamycin B, were used to inhibit acidification of the vacuolar...
Background/Methods: The role of vacuolar type H + -ATPases (v-ATPases) and pH gradient between the endocytic compartments and cytoplasm in the endocytosis of asialoglycoproteins was morphologically investigated in isolated rat hepatocytes using bafilomycin A1, a specific inhibitor of v-ATPases.Results: Fluorescent staining by acridine orange showed that bafilomycin A1 inhibited the acidification...
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