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Oxidative stress and inflammation exacerbate tissue damage in the brain after ischemic stroke. Dimethyl-fumarate (DMF) and its metabolite monomethyl-fumarate (MMF) are known to stimulate anti-oxidant pathways and modulate inflammatory responses. Considering these dual effects of fumarates, we examined the effect of MMF treatment after ischemic stroke in mice.Permanent middle cerebral artery occlusion...
Infiltration of myelin‐specific T cells into the central nervous system induces the expression of proinflammatory cytokines in patients with multiple sclerosis (MS). We have previously shown that myelin‐specific T cells are recruited into zones of axonal degeneration, where they stimulate lesion‐reactive microglia. To gain mechanistic insight, we used RNA microarray analysis to compare the transcript...
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