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Nanoparticle surface chemistry is a key component for nanoparticle‐cell interactions. Positively charged amines are hypothesized to drive these via Coulombic interactions with a negatively charged cell membrane. In article number 1802088, Calum Kinnear, Thomas L. Moore, Alke Petri‐Fink, and co‐workers report that the degree of amine methylation (i.e. amine bulkiness) is critical in mediating the nanoparticle‐cell...
Amino groups presented on the surface of nanoparticles are well‐known to be a predominant factor in the formation of the protein corona and subsequent cellular uptake. However, the molecular mechanism underpinning this relationship is poorly defined. This study investigates how amine type and density affect the protein corona and cellular association of gold nanoparticles with cells in vitro. Four...
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