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The p210Bcr/Abl and p190Bcr/Abl fusion oncoproteins are known to cause chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Bcr/Abl phosphorylates several proteins that can lead to leukemogenesis. Crk‐associated substrate lymphocyte type (Cas‐L)/human enhancer of filamentation‐1 (HEF1)/neural precursor cell expressed, developmentally down‐regulated 9 (NEDD9) is an adapter protein...
Recent studies have demonstrated overexpression of osteopontin (OPN) in ovarian clear cell carcinoma. Here, we revealed the role of OPN in invasiveness in ovarian clear cell carcinoma. We used immunofluorescence analysis to detect OPN in a total of 160 patient‐derived specimens. Ovarian clear cell carcinoma cell lines, RMG‐1 and TOV‐21G, were used to monitor changes in OPN and integrin levels, and...
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